Archives
Archives
Browse the full archive of past issues.
Translational Frontiers in Biomedicine and Health
Vol. 1 No. 1 (2025)
This inaugural issue of Emerging Frontiers in Translational Biomedicine and Health Sciences introduces the journal through four articles that together trace a path from bench science to public health. The issue is anchored in African contexts and shows how local questions about environmental exposure, infectious disease, and chronic illness can generate evidence that matters globally for patients, health systems, and policymakers.
The first two original articles focus on experimental models. One uses Bonny Light crude oil exposure in mice to show that co-administration of N-acetylcysteine and zinc sulfate can prevent neurobehavioral disturbances by modulating serotonergic and glutamatergic signaling, highlighting both the neurotoxic risk of oil pollution and a potential protective strategy. Another evaluates hydro-ethanol extracts of Khaya senegalensis stem bark, alone and with sulfasalazine, in a dextran sulphate sodium model of inflammatory bowel disease, demonstrating haematoprotective effects that support the plant’s role as a possible adjuvant therapy where standard drugs are costly or limited.
The remaining contributions move toward population and molecular therapeutics. A narrative review synthesizes diabetes education initiatives led by the International Diabetes Federation and African health systems, especially in indigenous communities, showing how community health workers, media, and structured self-care programmes can improve awareness and glycaemic control while revealing persistent structural gaps. The closing article investigates Spathodea campanulata as an antimalarial candidate, showing that its extract and isolated ellagic acid act against Plasmodium falciparum through multiple mechanisms with low haemolytic toxicity. Together, these four pieces define the journal’s vision of translational research that is mechanistically rigorous, locally grounded, and oriented toward practical improvements in patient care and population health.
Bridging research and clinical practice
Vol. 1 No. 2 (2025)
Volume 1, Issue 2 of Emerging Frontiers in Translational Biomedicine and Health Sciences brings together diverse yet interconnected studies spanning public health, occupational toxicology, experimental pharmacology, ethnomedicine safety, and healthcare systems research. Collectively, the contributions reflect the journal’s commitment to translating mechanistic science into meaningful population health impact.
The issue opens with a community-based investigation into malaria among under-five children in rural Delta State. The study documents persistently high malaria prevalence and demonstrates the significant protective effect of consistent insecticide-treated net use. It also highlights behavioral patterns and systemic gaps in timely healthcare access, underscoring the need for targeted, context-specific malaria control strategies driven by caregiver education and improved service delivery.
Expanding into occupational health, another study examines the biochemical impact of chronic exposure to metallic welding fumes, particularly when combined with smoking. By assessing serum copper levels alongside renal and hepatic biomarkers, the research identifies subtle but important disruptions in reno-hepatocellular homeostasis. These findings emphasize the compounded risks of environmental and lifestyle exposures and the importance of occupational health surveillance.
From an experimental perspective, the issue explores therapeutic modulation in diabetes through evaluation of D-Ribose-L-Cysteine in a high-fat diet/streptozotocin model. The study demonstrates improvements in hematological indices and key metabolic intermediates, suggesting antioxidant-based strategies may help mitigate diabetes-related oxidative and mitochondrial dysfunction.
Complementing therapeutic inquiry, a toxicological evaluation of Azanza garckeana fruit extract establishes a favorable safety profile and potential metabolic benefits, contributing evidence toward the scientific validation of traditional medicinal resources.
Finally, a review on pharmacy and pharmacology in hospital management underscores the growing role of pharmacological expertise in patient safety, medicines management, and healthcare governance. Together, the studies highlight the interplay between environmental exposure, behavioral practices, biochemical mechanisms, therapeutic innovation, and health systems strengthening in shaping health outcomes across populations.